Acknowledging that it is usually impossible to have entirely risk-free sex with another person, proponents of safe sex recommend that some of the following methods be used to minimize the risks of STI transmission and unwanted pregnancy.
- Immunization against various viral infections that can be transmitted sexually. The most common vaccines are HPV vaccine, which protects against the most common types of human papillomavirus that cause cervical cancer, and the Hepatitis B vaccine. Immunization before initiation of sexual activity increases effectiveness.
- Male circumcision and HIV: Some research has suggested that male circumcision can reduce the risk of HIV infection in some countries. The World Health Organization cites the procedure as a measure against the transmission of HIV between women and men; some African studies have found that circumcision can reduce the rate of transmission of HIV to men by up to 60%. Some advocacy groups dispute these findings. In sub-Saharan Africa, at least, condom use and behavior change programs are estimated to be more efficient and much more cost-effective than surgical procedures such as circumcision.
- Periodic STI testing has been used to reduce STIs in Cuba and among pornographic film actors. Cuba implemented a program of mandatory testing and quarantine early in the AIDS epidemic. In the US pornographic film industry, many production companies will not hire actors without tests for Chlamydia, HIV and Gonorrhea that are no more than 30 days old-and tests for other STIs no more than 6 months old. AIM Medical foundation claims that program of testing has reduced the incidence of sexually transmitted infection to 20% of that of the general population. Douching with soap and water disrupts the vaginal flora it might increase risk of infection.
- Monogamy or polyfidelity, practiced faithfully, is very safe (as far as STIs are concerned) when all partners are non-infected. However, many monogamous people have been infected with sexually transmitted diseases by partners who are sexually unfaithful, have used injection drugs, or were infected by previous sexual partners; the same risks apply to polyfidelitous people, who face higher risks depending on how many people are in the polyfidelitous group.
- For those who are not monogamous, reducing the number of one's sexual partners, particularly anonymous sexual partners, may also reduce one's potential exposure to STIs. Similarly, one may restrict one's sexual contact to a community of trusted individuals—this is the approach taken by some pornographic actors and other non-monogamous people.
- When selecting a sexual partner, some characteristics can increase the risks for contracting sexually transmitted diseases. These include an age discordance of more than five years; having an STI in the past year;problems with alcohol; having had sex with other people in the past year.
- Communication with one's sexual partner(s) makes for greater safety. Before initiating sexual activities, partners may discuss what activities they will and will not engage in, and what precautions they will take. This can reduce the chance of risky decisions being made "in the heat of passion".
- If a person is sexually active with a number of partners, regular sexual health check-ups by a doctor, and on noticing unusual symptoms seeking prompt medical advice; HIV and other infectious agents can be either asymptomatic or involve nonspecific symptoms which on their own can be misdiagnosed.
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